Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia

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Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs.Inactivating alterations of Polycomb repressive complex 2 components are dragon ball lg disney frequent in human ETP-ALL, but their functional role is largely undefined.We have studied the involvement of Ezh2 in a murine model of NRASQ61K-driven leukemia that recapitulates phenotypic and transcriptional features of ETP-ALL.Homozygous inactivation of Ezh2 cooperated with oncogenic NRASQ61K to accelerate leukemia onset.Inactivation of Ezh2 accentuated expression of genes highly expressed in human ETP-ALL and in normal murine early thymic progenitors.

Moreover, we found that Ezh2 contributes to the silencing of stem-cell- and early-progenitor-cell-associated genes.Loss of keychron m4 Ezh2 also resulted in increased activation of STAT3 by tyrosine 705 phosphorylation.Our data mechanistically link Ezh2 inactivation to stem-cell-associated transcriptional programs and increased growth/survival signaling, features that convey an adverse prognosis in patients.